Cryo-transfer System

Cryo-transfer System is a commonly used technique for biomedical and nanomaterials research.Cryogenic Sample Preparation。This technology can freeze liquid samples at aboutInstantly freeze in a low temperature environment of -172℃, forming an approximately 100 nm thick ice filmto allow the sample to enter while maintaining its original stateTransmission Electron Microscopy (TEM)Conduct observations.

Since most Biological samples and nano biomedical materialsTypically synthesized or existing in a solution environment, such as viral particles, protein complexes, liposomes, and nano drug carriers, if treated with traditional drying methods, it may cause changes in the sample structure or distortion of the aggregation state. Through low-temperature cryogenic sample preparation technology, liquid samples can be instantaneously vitrified, forming a stable ice film, and effectively preserving the nano particles in the solution.Original morphology, size distribution, and aggregation state。

With the Cryo-transfer system, samples can be transferred to the electron microscope observation platform under low temperature conditions, avoiding thawing or environmental contamination during the transfer process, allowing researchers to observeImages of nanostructures in close to liquid phase environmentThis technology breaks through the limitation of traditional electron microscopes that can only observe dry samples, and is widely used inVirus structure research, nano drug development, biomedical nanomaterial analysis, and observation of proteins and biological complexes. and other fields.

Cryo samples of liposomes can show the structure of the lipid bilayer and drug crystals of the particles in solution.